Effect of Sodium Bicarbonate on Haematological Parameters and Differential Cells in Plasmodium Berghei-infected Albino Mice

The current study evaluated the hematological changes in albino mice following infection with P. berghei and treatment sodium bicarbonate; an alkaline substance intended to alkalinize pH parasite environment. Twenty were randomly divided into five groups of four each. Groups 3, 4 5 test administered 84mg/kg b.w bicarbonate injection once, twice thrice respectively. 1 received dH20, group 2; only berghei. Three days later, parameters differential cells analyzed. PCV was significantly (p<0.05) lower 2(32.00±0.70), 3(34.00±0.70), 4(34.00±0.70), 5(33.00±0.70) compared control (35.00±0.70). Haemoglobin decreased (11.00±0.70) (11.80±0.70). WBC showed significant increase groups; 2(3600.00±70.71), 3(4600.00±70.71), 4(4800.00±70.71), (4800.00±70.71) (3200.00±70.71). Platelets 2(90.00±.70), 3(87.00±.70), 4(84.00±.70), 5(86.00±.70) (92.00±.70). percentage neutrophils higher 2(61.00±0.70), 3(58.00±0.70), 4(57.00±0.70), 5(57.00±0.70) (60.00±0.70). Leucocytes increased 2(36.00±0.70), 3(38.00±0.70), 4(38.00±0.70), 5(40.0±0.70) (32.00±0.70). Monocyte 2(2.00±0.07), 3(2.00±0.07), 4(2.00±0.10) 5(1.00±0.89) (4.00±0.07). Eosinophils 2(1.00±0.35), 4(3.00±0.70) (2.00±0.70). Basophils not detected neither groups. This revealed that infected caused elevation some cells.